This study aimed to find new treatments for carbapenem-resistant Pseudomonas aeruginosa, a bacteria that’s hard to treat with antibiotics. They screened many small molecules and found oxythiamine, a substance known to block certain enzymes in human cells. However, its ability to fight bacteria wasn’t known before. They discovered that oxythiamine can disrupt the metabolism of P. aeruginosa, making it vulnerable to other drugs, including some non-antibiotic ones. Further tests in mice showed that combining oxythiamine with certain drugs could effectively treat P. aeruginosa infections. This study suggests that targeting thiamine metabolism could be a promising strategy for developing new treatments against this bacteria.
