Research & Publications | RMDM Group

Research & Publications

Category: Pharma

Proteomic characterization of gastric cancer response to chemotherapy and targeted therapy reveals potential therapeutic strategies

Category: Diagnostics

Biomarker TKTL1: APC/CCDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression; this study postulates that TKTL1 is responsible and triggers cell division, which is ultimately the basis of tumor growth

Category: Diagnostics

Biomarkers Apo10 and TKTL1: Epitope-Detection in Monocytes (EDIM) as a new diagnostic approach for cholangiocellular, pancreatic and colorectal carcinoma; the study benchmarks PanTum Detect against CEA and CA19-9

Category: Diagnostics

TKTL1: levels stable during chemotherapy and the induction of dendritic cell vaccines

Category: Diagnostics

TKTL1: Overexpressed in HPV screening tests, confirming the presence of cervical cancer

Category: Pharma

Oxythiamine as mechanical inhibitor of TKTL1

Category: Pharma

TKTL1 and the sensitisation towards Paclitaxel

Category: Sugars

Tagatose and Diabetes

Category: Sugars

Ribose and Oxidative Stress

Category: Sugars

Galactose and Stomach Cancer

Category: Sugars

Galactose and Colorectal Cancer

Category: Sugars

Removal and prevention of dental plaque with d-tagatose

Category: Sugars

Anti-cavity effectiveness of D(+)-galactose

Category: Diagnostics

Reference: TKTL1 and Apo 10: The Biomarkers Behind our Cancer Early Detection Technology

Coy, J.F., Dressler, D., Wilde, D., Schubert, P. Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer. Clin Lab 2005 51: 257 – 273. All Publications & Patents – Unlinked Page – Accessible from Dr Coy’s Bio and Headline

Category: Diagnostics

Reference: TKTL1 and Apo 10: The Biomarkers Behind our Cancer Early Detection Technology

Xu, X., Zur Hausen, A., Coy, J.F., Löchelt, M. Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells. Int. J. Cancer 2009 124: 1330 – 1337.

Category: Diagnostics

Reference: TKTL1 and Apo 10: The Biomarkers Behind our Cancer Early Detection Technology

Sun, W., Liu, Y., Glazer, C., Shao, C., Bhan, S., Demokan, S., Zhao, M., Rudek, M., Ha, P., Califano, J. TKTL1 is Activated by Promoter Hypomethylation and Contributes to Head and Neck Squamous Cell Carcinoma Carcinogenesis through Increased Aerobic Glycolysis and HIF1α Stabilisation. Clinical Cancer Research 2010 Feb 1; 16(3): 857–866.

Category: Diagnostics

Reference: TKTL1 and Apo 10: The Biomarkers Behind our Cancer Early Detection Technology

Feyen, O., Coy, J.F., Prasad, V., Schierl, R., Saenger, J., Baum, R.P. EDIM-TKTL1 blood test: a noninvasive method to detect upregulated glucose metabolism in patients with malignancies. Future Oncol. 2012 Oct;8(10):1349-59.

Category: Diagnostics

Reference: TKTL1 and Apo 10: The Biomarkers Behind our Cancer Early Detection Technology

Grimm, M., Schmitt, S., Teriete, P., Biegner, T., Stenzl, A., Hennenlotter, J., Muhs, H.J., Munz, A., Nadtotschi, T., König, K., Sänger, J., Feyen, O., Hofmann, H., Reinert, S., Coy, J.F. A biomarker based detection and characterization of carcinomas exploiting two fundamental biophysical mechanisms in mammalian cells. BMC Cancer. 2013 Dec 4;13:569.

Category: Diagnostics

Reference: TKTL1 and Apo 10: The Biomarkers Behind our Cancer Early Detection Technology

Grimm, M., Feyen, O., Coy, J.F., Hofmann, H., Teriete, P., Reinert, S. Analysis of circulating CD14+/CD16+ monocytederived macrophages (MDMs) in the peripheral blood of patients with oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Mar;121(3):301-6.

Category: Diagnostics

Reference: TKTL1 and Apo 10: The Biomarkers Behind our Cancer Early Detection Technology

Diaz-Moralli, S.; Aguilar, E.; Marin, S.; Coy, J.F.; Dewerchin, M.; Antoniewicz, M.R.; Meca-Cortés, O.; Notebaert, L.; Ghesquière, B.; Eelen, G.; et al. A key role for Transketolase-like 1 in tumor metabolic reprogramming. Oncotarget 2016, 7, 51875–51897

Category: Diagnostics

Reference: TKTL1 and Apo 10: The Biomarkers Behind our Cancer Early Detection Technology

Coy, J.F. EDIM-TKTL1/Apo10 Blood Test: An Innate Immune System Based Liquid Biopsy for the Early Detection, Characterization and Targeted Treatment of Cancer. Int J Mol Sci. 2017 Apr 20;18(4). Review.

Category: Diagnostics

Reference: TKTL1 and Apo 10: The Biomarkers Behind our Cancer Early Detection Technology

Jayachandran, A.; Lo, P.H.; Chueh, A.C.; Prithviraj, P.; Molania, R.; Davalos-Salas, M.; Anaka, M.; Walkiewicz, M.; Cebon, J.; Behren, A. Transketolase-like 1 ectopic expression is associated with DNA hypomethylation and induces the Warburg effect in melanoma cells. BMC Cancer 2016, 16, 134.