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PanTum Detect: A True Game Changer in Cancer Diagnostics
- Non Invasive: a simple blood test/draw, done in a lab or clinic
- Accurate: 99.05 % specific and 97.5% sensitive (unmatched in cancer diagnostics)
- Universal: All cancers are detectable via the use of 2 unique novel biomarkers
- Affordable: the simple technology allows you to do a yearly screening check
- Quick turnaround: Results can be known within 24 hours
Can a blood test detect cancer?
PanTum Detect is a CE certified IVD blood test that can detect any cancer at any stage and which is based on the detection of epitopes in monocytes. Activated monocytes (macrophages) phagocytose unwanted cells/cell fragments from the whole body including solid tissues. As they return to the blood, macrophagescan be used for non-invasive detection of biomarkers, thereby providing high sensitivity and specificity, because the intracellular presence of biomarkers is due to an innate immune response.
Flow cytometry analysis of blood enables the detection of macrophages and phagocytosed intracellular biomarkers. In order to establish a pan-cancer test, biomarkers for two fundamental biophysical mechanisms have been exploited.
The DNaseX/Apo10 protein epitope is a characteristic of tumour cells with abnormal apoptosis and proliferation. Transketolase-like 1 (TKTL1) is a marker for an anaerobic glucose metabolism (Warburg effect), which is concomitant with invasive growth/metastasis and resistant to radical and apoptosis inducing therapies.
The test has already proven its capabilities with over 160,000 blood samples analysed across 40 tumour entities, its scorecard being:
• Sensitivity 97%
• Specificity 99%
Pantum Detect will not only help prevent Cancer related deaths via a regular screening check for healthy people but will also massively reduce the cost and strain on the Healthcare System with regards to relapses for Cancer survivors. It is truly a revolution in Cancer Care!
Spectacular Sensitivity & Specificity
Through EDIM technology we have achieved spectacular sensitivity and specificity results.
- PanTum Detect identifies 97.5% of 100 tumour patients.
- PanTum Detect reaches this high sensitivity because tumour-specific structures are well-conserved and highly concentrated inside the macrophages.
- Specificity is the most important KPI for screening tests.
- PanTum Detect reaches this high specificity by leveraging the extremely specific immune system (detection of biomarkers in macrophages).
E.D.I.M Epitome Detection In Macrophages
The EDIM technology makes use of the body’s immune system; these steps explain how the technology works:
- Macrophages migrate from blood into tissue.
- Macrophages phagocytose degenerated tumour cells.
- Macrophages with absorbed tumour-specific structures migrate back into the blood.
- PanTum Detect - The phagocytosed tumour cells are examined.
TKTL1 & Apo10
TKTL1 and Apo10 represent fundamental biological mechanisms in tumour cells.
PanTum Detect Cancer Test: Frequently Asked Questions
What is Pantum Detect?
PanTum Detect is a CE certified IVD blood test that can detect any cancer at any stage, and which is based on the detection of epitopes in monocytes.
How does PanTum Detect work?
Activated monocytes (macrophages) phagocytose unwanted cells/cell fragments from the whole body, including solid tissues. As they return to the blood, macrophages can be used for non-invasive detection of two biomarkers called Apo10 and TKTL1. This detection provides high sensitivity and specificity because the intracellular presence of biomarkers is due to an innate immune response.
Which types of cancer can be picked up by PanTum Detect?
Here’s an overview of over 40 cancer types which were detected in studies using the PanTum Detect tumour markers:
Adenocarcinoma, Aerodigestive Cancer, Astrocytoma, Pancreatic Cancer, Bladder Cancer, Bronchial Cancer, Breast Cancer, Cholangiocarcinoma (Biliary CA), Colorectal Cancer, DIPG / "Pons Gliomas", Triple Negative Breast Cancer, Ductal Carcinoma, Ovarian Cancer, Endometrial Cancer, Ependymoma, Gastroesophageal Transition Cancer, Cervical cancer, Uterine cancer, Brain tumour, Glioblastoma, Granulosa cell tumour, Gynaecologic cancers, Hepatoblastoma, HER2 positive breast cancer, Hyperplasia, Small cell lung cancer, Head and neck cancer, Lung cancer, Lymphoma tumours, Gastric cancer, Malignant conjunctival tumours, Medulloblastoma, Melanoma tumours, Nasopharyngeal carcinoma, Neoplastic lung tissue, Nephroblastoma, Non-metastatic rectal adenocarcinoma, Non-small cell lung cancer, Renal cancer, Oral squamous cell carcinoma OSCC, Estrogen receptor (ER)-positive breast cancer, Squamous intraepithelial neoplasm (SIN I - III), Squamous cell carcinoma, Squamous cell carcinoma of breast, Squamous cell carcinoma of the prostate, Squamous cell carcinoma of the esophagus (ESCC), Progesterone receptor (PR)-positive breast cancer, Prostate cancer, PSA-positive prostate cancer, PSMA-positive prostate cancer, Rectal cancer, Rhabdomyosarcoma, Thyroid cancer (follicular and papillary), Tumours of the eye appendage, Urothelial cancer, Vaginal cancer, Vulvar cancer
Note: Previously tested lymphomas and leukemias have also shown to be positive for PanTum Detect, but are not included in this list of solid tumours.
Disclaimer: This list contains information from publications and information from clinical practice in real testing situations.
Can you define these biomarkers and is the test cancer specific?
PanTum detect is a pan-cancer test, able to detect all types of cancer but not the variety of cancer that is present. The biomarkers that are exploited and unique to PanTum are for two fundamental biophysical mechanisms. The DNaseX (Apo10) protein epitope is a characteristic of tumour cells with abnormal apoptosis and proliferation. Transketolase-like 1 (TKTL1) is a marker for an anaerobic glucose metabolism (Warburg effect), which is concomitant with invasive growth/metastasis and resistant to radical and apoptosis-inducing therapies.
What is the technology used for analysis?
Flow cytometry analysis of blood enables the detection of macrophages and phagocytosed intracellular biomarkers. There is an integrated gating and algorithmic analysis within the flow cytometer.
What happens if a patient tests positive?
If a patient tests positive, the next step is to speak to their GP and potentially an oncologist. PanTum Detect does not determine which type of cancer the patient has, and so the entire clinical picture needs to be taken into account. This means looking at any symptoms the patient may have and performing primary care tests to discover where the cancer is located, what stage it is at and what the next steps in the patient’s care should be.
What are the specificity and sensitivity results of PanTum Detect?
PanTum Detect is extremely accurate, identifying cancer with 99.05% specificity and 97.5% sensitivity, minimizing the risk of false positives and false negatives.
Where can patients get a PanTum Detect test? Do they need a referral?
At present, we are working to make the PanTum Detect test available. We are discussing potential partnerships with clinics across London.
Are you a patient with questions about PanTum Detect? Keep an eye on our Twitter and LinkedIn page and website for further FAQs that will tell you everything that you need to know about our innovative early cancer detection screening solution.
PanTum Detect is the first line of defence against cancer, enabling it to be diagnosed at the earliest and most treatable stage. Find out more about PanTum Detect.
My PanTum Detect test is negative – what happens next?
This is great news! No immediate further test is required. We recommend that you schedule another PanTum Detect test within 12 months to provide ongoing peace of mind.
How accurate is PanTum Detect?
PanTum Detect is extremely accurate and limits the room for error. It is accurate to 99.05% specificity (true negatives) and 97.5% (true positives).
How does PanTum Detect work? Can I have a simple explanation?
PanTum Detect is a simple blood test that measures two markers within your immune system. If the markers pass a certain threshold, the test is positive.
Is the experience of getting a PanTum Detect blood test any different to a regular blood test?
No, PanTum Detect is performed in exactly the same way as a regular blood draw.
How long will it take to get the results of my PanTum Detect test?
It usually takes around a week to get the results of PanTum Detect.
Can PanTum Detect tell what type of cancer I have?
No, it cannot, it only detects the presence of cancerous cells. However, this can support the diagnosis of any type of suspected cancer, especially if the symptoms you have been experiencing are very mild or inconclusive.
Can PanTum Detect tell what stage of cancer I have?
Yes, PanTum Detect is able to indicate whether your cancer is likely to be early or late stage. This is thanks to the markers it detects. One marker indicates early-stage cancer, while the other is only present in later stage cancers.
How much does a PanTum Detect blood test cost?
The cost of PanTum Detect is comparative with the cost of other biomarker tests available in the market. Our partner clinics can give you further information on pricing.
How often should I have a PanTum Detect test?
PanTum Detect would be a great addition to any regular health monitoring and we recommend patients have the test at least once per year. This will help ensure that any cancer that may develop is detected at the earliest possible opportunity.
Is there any age limit for PanTum Detect?
No, there is no age limit. PanTum Detect can be successfully used to detect cancer in people of any age.
My PanTum Detect test is positive – what happens next?
If your test is found to be positive, you will need to schedule an appointment with your GP who can look at your entire clinical picture, including any symptoms that you may have. They will be able to refer you to an oncologist and talk to you about what investigations are needed to determine the type of cancer you have and the treatments that may be available.
Where can I get a PanTum Detect blood test? Do I need a referral?
Currently, the test is not available for appointments. We hope to be working with clinics and oncology centres in London and across the UK soon. PanTum Detect will also shortly be available at our global partner clinics in the Middle East. For a full list of RMDM’s diagnostic territories, please keep an eye on our Diagnostics page for updates.
A Global Target: A Universal Cancer Blood Test
At the forefront of medical research is the quest for a universal cancer blood test. PanTum Detect, the first blood test that can detect all cancers at any stage.