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The one stop shop for Healthier Living

After 23 years of Research and Development focusing on Early Detection, RMDM helped launch the pioneering cancer blood test and imaging screening program that can detect all cancers at any stage: PanTum Detect.

PanTum Detect + PET/CT Screening: A True Game Changer in Cancer Diagnostics

- Non Invasive: a simple blood test/draw, done in a lab or clinic

- Accurate: 99.05 % specific and 97.5% sensitive (unmatched in cancer diagnostics)

- Universal: All cancers are detectable via the use of 2 unique novel biomarkers

- Affordable: the simple technology allows you to do a yearly screening check

- Quick turnaround: Results can be known within 24 hours

- Possibility of localization and classification of detected tumours

- Exposure to radiation (PET/CT) only when necessary

 

Can a blood test detect cancer?

PanTum Detect is a CE certified IVD blood test that can detect any cancer at any stage and which is based on the detection of epitopes in monocytes. Activated monocytes (macrophages) phagocytose unwanted cells/cell fragments from the whole body including solid tissues. As they return to the blood, macrophages can be used for non-invasive detection of biomarkers, thereby providing high sensitivity and specificity, because the intracellular presence of biomarkers is due to an innate immune response.

Flow cytometry analysis of blood enables the detection of macrophages and phagocytosed intracellular biomarkers. In order to establish a pan-cancer test, biomarkers for two fundamental biophysical mechanisms have been exploited.

The DNaseX/Apo10 protein epitope is a characteristic of tumour cells with abnormal apoptosis and proliferation. Transketolase-like 1 (TKTL1) is a marker for an anaerobic glucose metabolism (Warburg effect), which is concomitant with invasive growth/metastasis and resistant to radical and apoptosis inducing therapies.

The test has already proven its capabilities with over 160,000 blood samples analysed across 40 tumour entities, its scorecard being:

  • Sensitivity 97%
  • Specificity 99%

Pantum Detect will not only help prevent cancer related deaths via a regular screening check for healthy people but will also massively reduce the cost and strain on the healthcare system. It is truly a breakthrough in cancer care!

PanTum Detect + Imaging: The Ideal Combination

Potentially dangerous tumors are able to be detected at a very early stage using imaging methods (such as MRI, PET/CT, etc.); but these methods cannot be used for a national screening program due to the high costs, lack of access, and potentially harmful radiation.

Combining PanTum Detect with modern imaging allows for safe cancer screening by filtering out non-cancer suspicious customers.

In a recent large-scale study ( study publication ) with over 5,000 subjects, PanTum Detect successfully identified cancer-suspicious customers justifying a follow-up examination (usually using imaging methods).

In a study of 5,000 healthy volunteers, 151 people received an imaging test as a result of a positive PanTum Detect result. 124 were diagnosed with cancer or premalignant cancer by imaging.

Private lecturer Dr G.-Andre Banat, MBA, summarizes the applicability of the new findings as follows:

"The study results suggest that this combination of the PanTum Detect blood test and imaging methods can close significant gaps in effective early cancer detection."

Spectacular Sensitivity & Specificity

Through EDIM technology we have achieved spectacular sensitivity and specificity results.

97.5% Sensitivity 

  • PanTum Detect identifies 97.5% of 100 tumour patients.
  • PanTum Detect reaches this high sensitivity because tumour-specific structures are well-conserved and highly concentrated inside the macrophages.

99.05% Specificity 

  • Specificity is the most important KPI for screening tests.
  • PanTum Detect reaches this high specificity by leveraging the extremely specific immune system (detection of biomarkers in macrophages).

E.D.I.M Epitome Detection In Macrophages

The EDIM technology makes use of the body’s immune system; these steps explain how the technology works:

  1. Macrophages migrate from blood into tissue.
  2. Macrophages phagocytose degenerated tumour cells.
  3. Macrophages with absorbed tumour-specific structures migrate back into the blood.
  4. PanTum Detect - The phagocytosed tumour cells are examined.
cancer progression infographic

TKTL1 & Apo10

TKTL1 and Apo10 represent fundamental biological mechanisms in tumour cells.

Pantum detect infographic

PanTum Detect Cancer Test: Frequently Asked Questions

A Global Target: A Universal Cancer Blood Test

At the forefront of medical research is the quest for a universal cancer blood test. PanTum Detect, the first blood test that can detect all cancers at any stage.