Introducing
[/ux_text] [divider] [ux_text font_size=”1.35″]PanTum Detect
Universal Cancer Test
[/ux_text] [/col] [col span=”6″ span__sm=”12″] [ux_image id=”543″] [/col] [/row] [/section] [section label=”Introduction” bg_color=”rgb(19, 32, 41)” padding=”120px” padding__sm=”80px”] [row style=”large” v_align=”middle”] [col span__sm=”12″ animate=”fadeInRight”] [ux_text text_color=”rgb(255,255,255)”]PanTum Detect finds cancer before it forms – universally
[/ux_text] [divider align=”center”] [/col] [/row] [row] [col span__sm=”12″] [ux_image id=”544″ image_size=”2048×2048″] [/col] [/row] [/section] [section label=”Media Right Large” bg_color=”rgb(165, 165, 165)” bg_overlay=”rgba(255, 255, 255, 0.85)” padding=”0px”] [row style=”collapse” width=”full-width” v_align=”middle”] [col span=”4″ span__sm=”12″ padding=”10% 10% 10% 10%” align=”center” max_width=”520px”]A global target: Universal cancer blood test
[divider align=”left”]At the forefront of medical research is the dream of a universal cancer blood test
[/col] [col span=”8″ span__sm=”12″] [ux_image id=”547″] [/col] [/row] [/section] [section] [row v_align=”middle”] [col span=”6″ span__sm=”12″] [ux_image id=”548″] [/col] [col span=”6″ span__sm=”12″]Early Detection is Key
[divider]Early detection in tumours significantly improves the survival rate
[/col] [/row] [/section] [section bg=”549″ bg_overlay=”rgba(14, 26, 51, 0.587)” padding=”60px”] [row] [col span=”2″ span__sm=”12″] [/col] [col span=”8″ span__sm=”12″] [ux_text text_color=”rgb(255,255,255)”]With missed diagnosed patients and fear of biopsies, there is a need for a drastic change in the detection of cancer
[/ux_text] [/col] [col span=”2″ span__sm=”12″] [/col] [/row] [/section] [row v_align=”middle”] [col span=”6″ span__sm=”12″]EDIM Epitome Detection In Macrophages
[divider]The EDIM technology makes use of the body’s immune system; this diagram explains how the technology works
[/col] [col span=”6″ span__sm=”12″] [ux_image id=”550″] [/col] [/row] [section label=”Introduction” bg_color=”rgb(29, 60, 77)” padding=”120px” padding__sm=”80px”] [row] [col span=”2″ span__sm=”12″] [/col] [col span=”8″ span__sm=”12″] [ux_text text_color=”rgb(255,255,255)”]TKTL1 and Apo10 represent fundamental biological mechanisms in tumour cells.
[/ux_text] [divider align=”center”] [/col] [col span=”2″ span__sm=”12″] [/col] [/row] [gap] [row style=”large” v_align=”middle”] [col span=”7″ span__sm=”12″ animate=”fadeInRight”] [ux_image id=”129″] [/col] [col span=”5″ span__sm=”12″] [ux_text text_color=”rgb(255,255,255)”]- Accumulates through disrupted cell apoptosis
- Independent of tumor type
- Disrupted apoptosis is root of malignant degeneration
- Indication of proliferation disorder / tumour
TKTL1 protein regulates aerobic glycolysis (fermentation of glucose even in presence of oxygen)
[/ux_text] [/col] [/row] [/section] [section bg_color=”rgb(18, 32, 41)” padding=”80px”] [row] [col span__sm=”12″] [row_inner] [col_inner span__sm=”12″] [ux_text text_color=”rgb(255,255,255)”]How can PanTum Detect revolutionize cancer screening?
[/ux_text] [divider align=”center”] [ux_text text_color=”rgb(255,255,255)”]PanTum Detect can identify cancer at any stage, the critical detection point is where it is still easily treatable.
[/ux_text] [/col_inner] [/row_inner] [ux_image id=”546″ image_size=”2048×2048″] [/col] [/row] [/section] [section label=”Introduction” bg_color=”rgb(247, 245, 244)” padding=”150px” padding__sm=”80px”] [row style=”collapse”] [col span=”6″ span__sm=”12″ span__md=”5″ padding=”0px 0px 0px 150px”] [ux_text text_align=”left” text_color=”rgb(0,0,0)”]PanTum Detect
[/ux_text] [divider] [ux_text text_align=”left” text_color=”rgb(0,0,0)”]A scoring test
[/ux_text] [/col] [col span=”6″ span__sm=”12″ span__md=”5″] [ux_text text_color=”rgb(0,0,0)”]- EDIM technology determines a score for each biomarker and both scores are then summed up for one final score
- A score of 245 is the cut-off point between positive and negative
- Above 245: the test is positive
- Below 245: the test is negative
- If the score is between 245 and 260, our recommendation is to run the test again, after 3 months have passed, to verify that it is indeed positive
- No medical conclusion should be drawn without the expert advice of a physician and without taking into account the patient’s entire clinical picture
The Illuminizer
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Capacity: 30 tests per run (2 hours)
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Size of a standard microwave (paramount for lab space)
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Built-in AI algorithm within which makes it very user friendly
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Specifically adapted to PanTum Detect and all future EDIM Technology tests
Technical Information
[/ux_text] [divider] [ux_text text_align=”left” text_color=”rgb(0,0,0)”]Benefits for Laboratories
[/ux_text] [/col] [col span=”6″ span__sm=”12″ span__md=”5″] [ux_text text_color=”rgb(0,0,0)”]- CE mark granted (EU approved)
- Time necessary to run one test and obtain the results: 12 h
- Storage Conditions of the PanTum Detect kit: between 2 and 8 degrees C (capacity for 100 tests)
- The Analytical Method is Flow Cytometry:
- The machine used during the development phase of EDIM was the FACS BD Canto II
- Labs can now also use our Illuminizer (smaller and more cost efficient machine than the BD Canto) specifically engineered for the EDIM technology
Frequently Asked Questions About PanTum Detect
[/ux_text] [divider width=”200px” height=”2px”] [/col] [col span=”6″ span__sm=”12″] [/col] [/row] [row] [col span=”6″ span__sm=”12″] [accordion] [accordion-item title=”What is PanTum Detect?”]PanTum Detect is a CE certified IVD blood test that can detect any cancer at any stage, and which is based on the detection of epitopes in monocytes.
[/accordion-item] [accordion-item title=”How does PanTum Detect work?”]Activated monocytes (macrophages) phagocytose unwanted cells/cell fragments from the whole body, including solid tissues. As they return to the blood, macrophages can be used for non-invasive detection of two biomarkers called Apo10 and TKTL1. This detection provides high sensitivity and specificity because the intracellular presence of biomarkers is due to an innate immune response.
[/accordion-item] [accordion-item title=”What types of cancer can be picked up by PanTum Detect”]Here’s an overview of over 40 cancer types which were detected in studies using the PanTum Detect tumour markers:
Adenocarcinoma, Aerodigestive Cancer, Astrocytoma, Pancreatic Cancer, Bladder Cancer, Bronchial Cancer, Breast Cancer, Cholangiocarcinoma (Biliary CA), Colorectal Cancer, DIPG / “Pons Gliomas”, Triple Negative Breast Cancer, Ductal Carcinoma, Ovarian Cancer, Endometrial Cancer, Ependymoma, Gastroesophageal Transition Cancer, Cervical cancer, Uterine cancer, Brain tumour, Glioblastoma, Granulosa cell tumour, Gynaecologic cancers, Hepatoblastoma, HER2 positive breast cancer, Hyperplasia, Small cell lung cancer, Head and neck cancer, Lung cancer, Lymphoma tumours, Gastric cancer, Malignant conjunctival tumours, Medulloblastoma, Melanoma tumours, Nasopharyngeal carcinoma, Neoplastic lung tissue, Nephroblastoma, Non-metastatic rectal adenocarcinoma, Non-small cell lung cancer, Renal cancer, Oral squamous cell carcinoma OSCC, Estrogen receptor (ER)-positive breast cancer, Squamous intraepithelial neoplasm (SIN I – III), Squamous cell carcinoma, Squamous cell carcinoma of breast, Squamous cell carcinoma of the prostate, Squamous cell carcinoma of the esophagus (ESCC), Progesterone receptor (PR)-positive breast cancer, Prostate cancer, PSA-positive prostate cancer, PSMA-positive prostate cancer, Rectal cancer, Rhabdomyosarcoma, Thyroid cancer (follicular and papillary), Tumours of the eye appendage, Urothelial cancer, Vaginal cancer, Vulvar cancer
Note: Previously tested lymphomas and leukemias have also shown to be positive for PanTum Detect, but are not included in this list of solid tumours. Disclaimer: This list contains information from publications and information from clinical practice in real testing situations.
[/accordion-item] [accordion-item title=”Can you define these biomarkers and is the test cancer specific?”]PanTum Detect is a pan-cancer test, able to detect all types of cancer but not the variety of cancer that is present. However, the imaging methods such as MRI, PET/CT, offer a high probability of localization and classification of detected tumours.
The biomarkers that are exploited and unique to PanTum are for two fundamental biophysical mechanisms. The DNaseX (Apo10) protein epitope is a characteristic of tumour cells with abnormal apoptosis and proliferation. Transketolase-like 1 (TKTL1) is a marker for an anaerobic glucose metabolism (Warburg effect), which is concomitant with invasive growth/metastasis and resistant to radical and apoptosis-inducing therapies.
[/accordion-item] [accordion-item title=”What is the technology used for analysis?”]Flow cytometry analysis of blood enables the detection of macrophages and phagocytosed intracellular biomarkers. There is an integrated gating and algorithmic analysis within the flow cytometer.
[/accordion-item] [accordion-item title=”What happens if a customer receives a tumour-suspicious result?”]If a customer receives a tumour-suspicious result, a prompt and efficient physician consultation will be organized, and the follow-up examination (such as PET/CT or MRI) and a referral to an oncologist in case the initial suspicion is confirmed.
[/accordion-item] [accordion-item title=”What are the specificity and sensitivity results of PanTum Detect”]PanTum Detect is extremely accurate, identifying cancer with 99.05% specificity and 97.5% sensitivity, minimizing the risk of false positives and false negatives.
[/accordion-item] [accordion-item title=”Where can customers get a PanTum Detect test? Do they need a referral?”]At present, we are working to make the PanTum Detect test available. We are discussing potential partnerships with clinics across London. Keep an eye on our Twitter and LinkedIn page and website for updates on when the PanTum Detect + Imaging Screening Program will be available.
[/accordion-item] [accordion-item title=”My PanTum Detect test is NOT tumour-suspicious. What happens next?”]This is great news! No immediate further test is required. We recommend that you schedule another PanTum Detect test within 12 months to provide ongoing peace of mind.
[/accordion-item] [/accordion] [/col] [col span=”6″ span__sm=”12″] [accordion] [accordion-item title=”How does PanTum Detect work? Can I have a simple explanation?”]PanTum Detect is a simple blood test that measures two markers within your immune system. If the markers pass a certain threshold, the test result is tumour suspicious.
[/accordion-item] [accordion-item title=”Is the experience of getting a Pantum Detect blood test any different to a regular blood test?”]No, PanTum Detect is performed in exactly the same way as a regular blood draw.
[/accordion-item] [accordion-item title=”How long will take to get the results of my PanTum Detect test?”]It usually takes around a week to get the results of PanTum Detect.
[/accordion-item] [accordion-item title=”Can PanTum Detect tell what type of cancer I have?”]No, PanTum Detect can only detect the presence of cancerous cells. However, this can support the diagnosis of any type of suspected cancer, especially if the symptoms you have been experiencing are very mild or inconclusive. Imaging methods such as MRI, PET/CT, offer a high probability of localization and classification of detected tumours.
[/accordion-item] [accordion-item title=”Can PanTum Detect tell what stage of cancer I have?”]Yes, PanTum Detect is able to indicate whether your cancer is likely to be early or late stage. This is thanks to the markers it detects. One marker indicates early-stage cancer, while the other is only present in later stage cancers.
[/accordion-item] [accordion-item title=”How much does a PanTum Detect blood test cost?”]The cost of PanTum Detect is comparative with the cost of other biomarker tests available in the market. Our partner clinics can give you further information on pricing.
[/accordion-item] [accordion-item title=”How often should I have a PanTum Detect test?”]PanTum Detect would be a great addition to any regular health monitoring and we recommend patients have the test at least once per year. This will help ensure that any cancer that may develop is detected at the earliest possible opportunity.
[/accordion-item] [accordion-item title=”Is there any age limit for PanTum Detect?”]No, there is no age limit. PanTum Detect can be successfully used to detect cancer in people of any age.
[/accordion-item] [accordion-item title=”My PanTum Detect test result is tumour-suspicious – what happens next?”]If you receive a tumour-suspicious result, a prompt and efficient physician consultation will be organized, and the follow-up examination (such as PET/CT or MRI) and a referral to an oncologist in case the initial suspicion is confirmed.
[/accordion-item] [accordion-item title=”Where can I get a PanTum Detect blood test? Do I need a referral?”]Currently, the test is not available for appointments. We hope to be working with clinics and oncology centres in London and across the UK soon. PanTum Detect will also shortly be available at our global partner clinics in the Middle East. For a full list of RMDM’s diagnostic territories, please keep an eye on our Diagnostics page for updates.
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